Where there’s one…(1)

A curious feature of chronic pain conditions is that people tend to have more than one. The term “chronic overlapping pain conditions” (COPCs) describes the co-occurrence of more than one of ten named conditions (1). Imagine a Venn-diagram type overlap of the symptoms of each condition.

The ten named conditions are not meant to be an exhaustive list but are conditions identified by the National Institutes of Health and the US Congress as exemplars of COPCs. The list has grown from an original six to ten conditions: temporomandibular disorder, fibromyalgia, irritable bowel syndrome, vulvodynia, myalgic encephalomyelitis/chronic fatigue syndrome, interstitial cystitis/painful bladder syndrome, endometriosis, chronic tension-type headache, migraine headache, and chronic lower back pain (1, 2).

Sometimes I feel like I’m participating in a Pokemon “collect ’em all” game with pains. Though I don’t know what I’m collecting, when I’ll next get a new one, or how many are left to come.

My own unfolding of my current constellation of pain symptoms/syndromes goes like this:

That list reduces years of pain and illness down to four bullet points. That is actually quite distressing to read. Seeing those bullet point feels like my experience is minimised. And I wrote it!

Some of these chronic pains started with an underlying structural cause. The TMJ disorder was likely caused by teeth crowding impacting on the space between the disc and ball of the TMJ joint. That lack of space was fixed with many years of dental work. Yet, I still experience residual pain.

The chronic dislocating patella was likely caused by an overly short tendon on the outside of my left leg preventing muscle forming on the opposite side. The tendon was therefore pulling the patella and there was no muscle to hold it. After several years of physiotherapy didn’t result in muscle build up, I had surgery to lengthen the tendon. More physiotherapy did result in muscle growth and the kneecap stopped dislocating. Yet, I still experience residual pain.

The carpal tunnel syndrome was likely caused by inflammation or a narrow gap putting pressure on nerves. After physiotherapy didn’t stop the progression of the pain or nerve damage, I had surgery to widen the space around the nerves in both hands. Yet I still experience residual pain.

The pain I link to my jaw, knee, and hands is different than it was pre-treatment. There was something going on, some on-going tissue damage, that was fixed by the interventions. The impairments in function that accompanied the pain were fixed by the interventions. I can open my mouth. My knee doesn’t dislocate. My hands don’t tingle and I can use them adequately. Yet a different kind of pain persisted and slowly spread throughout my body.

If we pause and think about what pain is, having more than one type of pain, or a more widespread pain, makes sense. Pain is linked to protection. It is an experience generated to prompt protection of body-tissue.

Thinking beyond the pain itself can also shine light on the broader protective processes. So far when I’ve written about pain here in Pinches, I’ve narrowed my description to focus on the pain. Theories of pain actually propose that while pain is the experience of perceived threat to body tissue, it is associated with many other protective physiological responses (3). Pain is just one output. Our motor, immune, sympathetic nervous, and hormonal systems are all recruited to protect us too (3).

Thinking about pain in this way can help to make sense of the association of chronic pain with other chronic conditions. Chronic pain, or pains, are also co-morbid (occur together) with other conditions; not only conditions with pain as the dominant feature. Those chronic overlapping pain conditions and co-morbidities are chronic protective processes in action (2, 3).

Over the last few years I’ve collected a series of non-pain symptoms and associated diagnoses which suggest that my body is functioning differently than it should (or how I would like it to):

  • selective IGA deficiency (immune system; likely present since birth)
  • hidradenitis suppurativa (autoinflammatory skin condition; present since my early 20s, recently progressed enough to be diagnosed)
  • endometriosis (symptoms for years, waiting for a surgery to confirm diagnosis; associated with inflammation)

Of course, I’m speculating that my chronic pain and other chronic conditions are related to an overactive threat protection system. I’ll likely never know in my case for sure. However I can say that I’m not the only person to experience multiple chronic conditions. Having more than one chronic condition is part of day-to-day life for many people, not a rare exception (1).

In the next pinch, I’ll use my experience to illustrate some of the potential impacts of an overactive threat protection system on day-to-day life and on wider interactions with the mechanisms and systems of a big society.

1. Maixner, W., Fillingim, R. B., Williams, D. A., Smith, S. B., & Slade, G. D. (2016). Overlapping chronic pain conditions: implications for diagnosis and classification. Journal of Pain, 17, T93 – T107. https://doi.org/10.1016/j.jpain.2016.06.002

2. Veasley C., Clare D., Clauw D. J., Cowley T., Nguyen R. H. N., Reinecke P., Vernon S. D., Williams D. A. (May, 2015). Impact of chronic overlapping pain conditions on public health and the urgent need for safe and effective treatment: 2015 analysis and policy recommendations [White Paper]. Chronic Pain Research Alliance. http://www.chronicpainresearch.org/public/CPRA_WhitePaper_2015-FINAL-Digital.pdf.

3. Moseley, G. L. (2007). Reconceptualising pain according to modern pain science. Physical Therapy Reviews, 12, 169–178. https://doi.org/10.1179/7108331907X223010

3 thoughts on “Where there’s one…(1)

  1. Pete Keyanonda

    Is chronic fatigue a co morbidity thing associated with chronic pain too? I find after bouts of pain the fatigue is crippling. All consuming. It’s like in my bones and in my soul. Can’t handle. Having the pain and the chronic fatigue is like a double edged knife in my heart.


    1. I didn’t mean to like this comment and now it’s stuck. Please see my like as acknowledgement.

      Unfortunately, yes! Many people with chronic pain experience fatigue and vice versa. A 2010 study reported 60% of the people they asked with chronic pain experienced chronic fatigue too. There’s still a lot we don’t know about the relationship and underlying causes of co-occurring pain and fatigue. Exemplified by a 2018 paper’s title: “Tired of pain? Toward a better understanding of fatigue in chronic pain”. The 2018 paper’s authors report that “in 5 of the 6 prospective studies included, fatigue developed after pain onset, suggesting that chronic pain might cause fatigue.” The mechanism in these cases is therefore likely something pain-related or underlying both the pain and fatigue. Rest is a way the body promotes healing. If your threat protection system has got all these signals that something is wrong, it’s not surprising fatigue is a result. Not surprising, but devastating. You know I experience fatigue by how much I need to sleep when I come visit you. When the pain is flaring up, the fatigue is worse, I describe it as crushingly weary. It’s awful. I hear how awful it is for you in your comment x

      Creavin, S. T. , Dunn, K. M. , Mallen, C. D. , Nijrolder, I. & van der Windt, D. A. (2010). European Journal Of Pain, 14, 327–334. doi: 10.1016/j.ejpain.2009.05.010.

      Van Damme, S. Becker, S., & Van der Linden, D. (2018). Tired of pain? Toward a better understanding of fatigue in chronic pain. Pain, 159, 7–10. doi: 10.1097/j.pain.0000000000001054


  2. Pingback: The pain of public transport – Pinches of Pain

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s